Japan has been a key player in the global competition based on scientific and technological innovation. Through a series of Science and Technology Basic Plans, the national government sought to restructure the country’s approach to scientific and technological development, with initiatives ranging from a fundamental restructuring of public universities to major investments in regional clusters. Collaboration with business has likewise been a centerpiece of the Japan strategy, as has high level political leadership of the broad initiative. This paper examines the international and national context of Japanese innovation, outlines the core elements of the Japanese innovation strategy, and provides preliminary observations about the first decade of the country’s extensive efforts to establish Japan as a global leader in the commercialization of science and technology.